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Korean Journal of Clinical Oncology > Article
Korean J Clin Oncol. 2008;4(1): 25-32.         doi: https://doi.org/10.14216/kjco.08005
Prognostic Significance of E-cadherin, -catenin, c-erbB2, and p53 in Gastric Cancer
Dong Won Kim, Yong Jin Kim, Gil Ho Kang, Gyu Seok Cho, Moon Soo Lee, Kyung Yul Hur, Jae Joon Kim, So-Young Jin
1Department of Surgery, Soonchunhyang University Medicine School
2Clinical Pathology, Soonchunhyang University Medicine School
위암에서 E-cadherin, β-catenin, c-erbB-2, 그리고 p53 발현의 예후 인자로서 임상적 유용성
김동원, 김용진, 강길호, 조규석, 이문수, 허경열, 김재준, 진소영
1순천향대학교 의과대학 외과학교실
2순천향대학교 의과대학 임상병리학교실
Corresponding Author: Yong Jin Kim ,Tel: +82-2-709-9479, Fax: +82-2-795-1687, Email: yjkim@hosp.sch.ac.kr
Received: April 28, 2008;  Accepted: May 19, 2008.
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Purpose: Although the TNM stage is the most important prognostic factor for gastric cancer, there is a need for new prognostic factors, because the prognosis varies among patients of the same stage. The aim of this study was to clarify the prognostic significance of E-cadherin, -catenin, c-erb B2, and p53 in patients with gastric cancers. Materials and
Methods: Loss of membranous expression of E-cadherin & -catenin, abnormal c-erb B2 membranous expression, and overexpression of p53 were investigated immunohistochemically using 96 cases of paraffin embedded tissue of gastric carcinomas at Soonchunhyang University in 2002. These were correlated with the clinicopathological parameters such as age, depth of invasion, lymph node metastasis, histology, Lauren classification, and survival were analyzed retrospectively. There were 61 males and 35 females (1.7:1) with a mean age of 57.5 years (range:36~73 years).
Results: The percentage of abnormal expression of E-cadherin, -catenin, c-erbB-2, and p53 were 76/96 (79.2%), 62/96 (64.6%), 48/96 (50%), and 45/96 (46.9%), respectively. Abnormal expression of E-cadherin occurred more frequently in serosa-invasive than serosa-noninvasive groups (p<0.05). In all cases with preserved expression of E-cadherin, recurrence was not occured regardless of the stage. Abnormal expression of -catenin, c-erb B2, and p53 were not related with clnicopathological parameters. The prognosis was associated with lymph node metastasis (p=0.0087) and serosa invasion (p=0.0277) in an univariate analysis. Lymph node metastasis is an independent prognostic factor in patients with gastric cancers(p=0.0047).
Conclusion: Although this study was performed with small number of cases and shortage of the follow-up time, E-cadherin showed the possibility as one of prognostic factors in gastric cancer.
Keywords: Gastric cancer | Prognostic factor | Immunohistochemistry | E-cadherin
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