| Clinicopathologic Characteristics of HER-2/neu
Overexpressing Breast Cancer |
| Chul Nam Kim |
| Department of Surgery, Ilsan Paik Hospital, Inje Universitiy School of Medicine |
| HER-2/neu유전자 과발현 유방암의 임상병리학적 특성 |
|
김철남 |
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인제대학교 의과대학 일산백병원 외과 |
| Corresponding Author:
Chul Nam Kim ,Tel: +82-31-910-7300, Fax: +82-31-910-7319, Email: cnkim@ilsanpaik.ac.kr |
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Received: April 20, 2009; Accepted: May 19, 2009. |
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| ABSTRACT |
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Purpose : Clinicopathologic factors associated with prognosis in breast cancer patients have varied. HER-2/neu gene
amplification and/or protein overexpression occur in 14-30% of all cases of breast cancer. Among clinicopathologic factors,
HER-2/neu gene status has been suggested to be a significant prognostic indicator for breast cancer. The objective of this study
was to determine whether HER-2/neu gene expression is associated with other clinicopathologic factors in breast cancer.
Methods : The expression of HER-2/neu, Ki-67, p53, estrogen receptor and progesterone receptor was determined immunohistochemically
and medical records were reviewed in 119 breast cancer patients, including 87 patients that demonstrated the
absent of HER-2/neu expression and 32 patients with the present of HER-2/neu expression. Results : HER-2/neu expression
was noted in 32 patients (26.9%) of the 119 breast cancer patients. Of the 87 patients(73.1%) with absent of HER-2/neu expression.
There was a significant correlation between HER-2/neu expression and the nodal status (p=0.023), lymphovascular invasion(
p=0.029), histologic grade(p=0.041), nuclear grade(p=0.001), estrogen receptor status(p=0.001) and progesterone
receptor status(p=0.004). Nuclear grade was statistically significant association factor with HER-2/neu expression status independently
in multivariate analysis.(p=0.041, relative risk 0.177, 95% CI 0.043-0.733) Conclusion : This study demonstrates the
potential value of the lymph nodal status, lymphovascular invasion, histologic grade, nuclear grade and hormonal receptor status
correlating with the status of HER-2/neu expression in human breast cancer. |
| Keywords:
HER2/neu | Clinicopathologic feature | Breast cancer |
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