Received: November 20, 2010; Accepted: December 23, 2010.
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ABSTRACT
Purpose: The aim of this study was to evaluate the diagnostic value of 18F-FDG PET for detecting nodal metastasis,
distant metastasis and peritoneal metastasis in patients with advanced gastric cancer with perigastric fat infiltration
and to identify histopathologic parameters that may affect FDG uptake of primary tumor and regional LN among
these patients
Materials and Methods: From September 2006 to August 2007, 101 patients diagnosed with gastric cancer by
gastrofiberscopic biopsy and shown as having findings of perigastric fat infiltration on CT were enrolled. The
sensitivities, specificities, positive predictive value, and negative predictive value of PET-CT were evaluated in the
detection of nodal metastasis and peritoneal metastasis. In cases with perceptible FDG uptake in primary tumor
and regional lymph node, the standardized uptake value (SUV) was calculated. The clinicopathologic results such
as depth of invasion (T stage), tumor size, lymph node metastasis, tumor histological type, Lauren classification
were reviewed.
Results: PET-CT had a lower sensitivity in detecting of nodal metastasis and peritoneal metastasis. Borrmann type
and tumor diameter was related to the degree of FDG uptake in primary tumor and regional lymph node.
Conclusions: It might be concluded that PET-CT has little role in the detection of nodal metastasis and peritoneal
metastasis due to its low sensitivity.
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