Expression of ER, p53 and HER-2/neu in medullary carcinoma
and infiltrating ductal carcinoma with medullary feature

Lee, Jong Eun; Lee, Jihyoun; Han, Sun Wook; Bae, Sang Ho; Gang, Gil Ho; Kim, Sung Yong; Baek, Moo Jun; Park, Nae Kyeong; Lim, Cheol Wan; Lee, Moon Soo; Kim, Chang Ho; Lee, Min Hyuk; Lee, Jee Hye; Cho, Hyun Duk; Oh, Mee Hye; Kim, Eui Han

doi:2010.6.1.79

Korean Journal of Clinical Oncology > Article

Original Article

Korean Journal of Clinical Oncology 2010;6(1): 79-87.

전형적인 수질성 유방암과 수질암 모양을 가진 침윤성 유관암에서 Biologic marker인 ER, p53과 HER-2/neu의 발현 양상

이종은¹, 이지현¹, 한선욱¹, 배상호¹, 강길호¹, 김성용¹, 백무준¹, 박내경¹, 임철완¹, 이문수¹, 김창호¹, 이민혁¹, 이지혜², 조현득², 오미혜², 김의한²

¹순천향대학교 의과대학 외과학교실
²순천향대학교 의과대학 병리학교실

Expression of ER, p53 and HER-2/neu in medullary carcinoma and infiltrating ductal carcinoma with medullary feature

Jong Eun Lee¹, Jihyoun Lee¹, Sun Wook Han¹, Sang Ho Bae¹, Gil Ho Gang¹, Sung Yong Kim¹, Moo Jun Baek¹, Nae Kyeong Park¹, Cheol Wan Lim¹, Moon Soo Lee¹, Chang Ho Kim¹, Min Hyuk Lee¹, Jee Hye Lee², Hyun Duk Cho², Mee Hye Oh², Eui Han Kim²

¹Department of Surgery, Soonchunhyang University, College of Medicine, Cheonan Hospital, Chungnam, Korea
²Department of Pathology, Soonchunhyang University, College of Medicine, Cheonan Hospital, Chungnam, Korea

Corresponding Author: Sung Yong Kim ,Tel: +82-41-570-3636, Fax: +82-41-571-0129, Email: sykim@schca.ac.kr

Received: May 20, 2010; Accepted: June 23, 2010.

ABSTRACT

Purpose : Breast cancer with BRCA1 variation has similar microscopic appearance with medullary cancer, and has pushing margins. These cases are classified as infiltrating ductal carcinoma with medullary feature nowadays. In general, medullary cancer expresses positive p53 and negative HER-2/neu. Positive ER is related to good prognosis, and well differentiated cancer is related to positive predictive value. Based on these correlations, the study was designed to make differentiation between medullary cancer and infiltrating ductal carcinoma with medullary feature with expression of ER, p53, and HER-2/neu. Material and Methods : Specimen of 10 medullary cancer and 20 infiltrating ductal carcinoma with medullary feature, which were obtained from biopsy or operation at breast clinic in Soonchunhyang university Cheonan hospital underwent immunohistochemistry stain. Results : ER expression in medullary cancer was negative in 9 out of 10 cases. In infiltrating ductal carcinoma with medullary feature, it was negative in 14 out of 20 cases, and there was expression of grade 3 in 5 cases. Expression of p53 in medullary cancer was grade 1 in 5, and grade 3 in 5 among 10 cases. In infiltrating ductal carcinoma with medullary feature, it was grade 1 in 7, and grade 3 in 11 among 20 cases. The expression of HER-2/neu in medullary cancer was score 0 in 2, and score 3 in 4 among 10 cases. It was expressed as score 0 in 8, and score 3 in 10 among 20 cases with infiltrating ductal carcinoma with medullary feature. Conclusion : Expression of p53 and HER-2/neu was not useful in differentiating medullary cancer and infiltrating ductal carcinoma with medullary feature. ER was useful only in cases with positive ER expression. Microscopic findings of necrosis and stromal feature, or ultrasonographic findings of tumor margin was considered to be more valuable in discriminating the 2 diseases.

Keywords: Medullary | Breast Carcinoma | ER | p53 | Her-2/neu