| The impact of the serum CEA on pathological tumor response after preoperative
chemoradiotherapy with total mesorectal excision for rectal cancer |
| HongJin Shim1, Jeonghyun Kang1, Young Wan Kim2, Hyung Soon Lee1, Hyuk Hur1, Byung Soh Min1, Kang Young Lee1, Nam Kyu Kim1 |
1Department of Surgery Yonsei University Health System, Yonsei University College of Medicine, Seoul, South Korea
2Department of Surgery Bucheon Hospital, Suncheonhyang university College of Medicine, Seoul, South Korea |
| 수술전 화학방사선 요법을 시행 받은 직장암에서 혈중 암종배아항원과 조직학적 치료반응도와의 상관관계분석 |
|
심홍진1, 강정현1, 김영완2, 이형순1, 허혁1, 민병소1, 이강영1, 김남규1 |
1연세대학교 의과대학 외과학교실
2순천향대학교 부천병원 외과학교실 |
| Corresponding Author:
Nam Kyu Kim ,Tel: +82-2-2228-2117, Fax: +82-2-313-8289, Email: namkyuk@yuhs.ac |
|
Received: May 20, 2010; Accepted: June 23, 2010. |
|
|
Share : 
|
| ABSTRACT |
Purpose: This study was designed to assess whether serum CEA is associated with pathological tumor response in
rectal cancer patients who underwent preoperative chemoradiation therapy (CRT) with total mesorectal excision (TME).
Methods: Eighty-five patients with rectal cancer who were treated by preoperative CRT followed by TME were
enrolled between August 2005 and December 2007. 5-FU based chemotherapy and 5040 cGy of radiation were
delivered. Serum CEA was measured pre-CRT, post-CRT, and post-TME period. Among 85 patients, 29 patients did
not have post-CRT CEA level. Pathological tumor response (ypTNM stage) was categorized into two groups as
follows; favorable response group (group A: n=28, pathological complete response and ypTNM I) vs unfavorable
response group (group B: n=57, ypTNM II and III). Median follow-up period was 29.2 months (range 1.1-50.2 months).
Results: There were no differences between favorable and unfavorable response group with respect to age,
gender, tumor location, lymphovascular invasion, and perineural invasion (Table 1). Anal sphincter preservation
surgery was more commonly performed in the group A when compared with group B (26 (92.9%) vs. 41 (71.9%))
(p=0.026). Well and moderately differentiated histology were more commonly found in the group A (26(92.9%) vs.
40(70.2%) (p=0.018). Low level of pre-CRT CEA (<5ng/ml) was more commonly found in the group A (26(92.9%) vs.
30 (52.6%) (p=0.000). However, there was no difference between group A and B with regard to post-CRT CEA and
post-TME CEA. Logistic regression analyses showed that pre-CRT CEA (<5ng/ml) and sphincter preservation
surgery were associated with favorable pathological tumor response.
Conclusions: Low level of pre-CRT CEA (<5ng/ml) is predictive of favorable pathological tumor response but serum
level of post-CRT and post-TME CEA did not have significant association with tumor response. This result should
be validated in larger prospective randomized study near future. |
| Keywords:
Preoperative chemoradiation | rectal cancer | CEA | pathologic response |
|
|
|
PDF Links
Full text via DOI
Download Citation 
