| Clinical significance of tumor size in Gastric cancer |
| Hakjin Kim1, Youjin Jang1, Jonghan Kim1, Sungsoo Park1, Sungheum Park1, Seungjoo Kim1, Youngjae Mok1, Jongsuk Kim1, Jungmin Park2, Kyungsook Yang3 |
1Department of Surgery, Korea University College of Medicine, Seoul, Korea
2Department of Surgery, Joongang University College of Medicine, Seoul, Korea
3Department of Medical statistics, Korea University College of Medicine, Seoul, Korea |
| 위암에서 종양 크기의 임상적 의의 |
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김학진1, 장유진1, 김종한1, 박성수1, 박성흠1, 김승주1, 목영재1, 김종석1, 박중민2, 양경숙3 |
1고려대학교 의과대학 외과학 교실
2중앙대학교 의과대학 외과학교실
3고려대학교 의학 통계학 교실 |
| Corresponding Author:
Jongsuk Kim ,Tel: +82-2-920-5401, Fax: +82-2-928-1631, Email: chongsuk@korea.ac.kr |
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Received: May 20, 2010; Accepted: June 23, 2010. |
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| ABSTRACT |
Purpose: The objectives of this study were to investigate the impact of the tumor size on survival of gastric cancer
patients who underwent curative resection and to evaluate relationships between tumor size and lymph node
metastasis
Materials and
Methods: We retrospectively studied 928 gastric cancer patients who underwent curative resection
at Korea University Medical Center from 1992 to 2002. The cut-off value of tumor size was decied as the smallest
value that showed significantly survival difference by COX proportional hazard model. The clinicopathological
factors associated with tumor size were analyzed by using univatiate and multivariate analyses. And ROC curves
were applied to measure cut-off value of tumor size that impact on lymph node metastasis.
Results: In COX proportional hazard model , the cut-off value of tumor size was 7cm that impact on prognosis. The
tumor location, depth of invasion, lymph node metastasis, and cell differenciation were significantly different
according to the tumor size. The Age, depth of invasion, tumor size and lymph node metastasis were independent
prognostic factors by using multivariate analyses. In Releavance between the tumor size and lymph node
metastasis, there were significant difference stage I, III, and whole patients group. And the each cut-off values were
1.5cm, 6cm, and 3.3cm
Conclusion: Tumor size was significant prognostic factor and important predictive value for lymph node metastasis
in gastric cancer. So tumor size will useful parameter to perform EMR in early gastric cancer or to plan further
management of advanced gastric cancer. |
| Keywords:
Gastric cancer | tumor size | Lymph node metastasis | Clinical significance |
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