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Korean Journal of Clinical Oncology > Article
Korean J Clin Oncol. 2011;7(2): 28-36.         doi: https://doi.org/10.14216/kjco.11016
Pregnancy-Associated Breast Cancer Compared to Invasive Ductal Carcinoma Less Than 40 Year-Old of Age
Ban Seok Yang1, Seho Park1, So Hee Lee1, Hyung Seok Park1, Hyewon Hwang1, Jun Sang Lee1, Si Mon Ko1, Seung Il Kim1, Byeong-Woo Park1, 2
1Department of Surgery, Yonsei University College of Medicine, Seoul, Korea
2Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea
임신성 유방암과 40세 미만의 유방암과 비교
양반석1, 박세호1, 이소희1, 박형석1, 황혜원1, 이준상1, 고시몬1, 김승일1, 박병우1, 2
1연세대학교 의과대학 외과학교실
2연세대학교 의과대학 Brain Korea 21 Project for Medical Science
Corresponding Author: Seho Park ,Tel: +82-2-2228-2100, Fax: +82-2-313-8289, Email: psh1025@yuhs.ac
Received: September 23, 2011;  Accepted: October 20, 2011.
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Purpose : The aims of this study were to investigate clinicopathological characteristics and outcomes of pregnancy-associated breast cancer (PABC) and to determine the implications of pregnancy itself on the prognosis of PABC. Methods : Clinicopathological features, treatment patterns, and survival of 14 PABC patients were compared to those of 855 invasive ductal carcinoma (IDC) patients under 40 years of age, who were treated between 1987 and 2007, using a chi-square test, the Kaplan-Meier method, and Cox’s hazards models. PABC was defined as breast cancer diagnosed during pregnancy or within the first year after delivery. Results : Among 14 PABCs, 7 were diagnosed during pregnancy and 7, during the first postpartum year. The mean duration of the symptoms was 7.6 months. The mean age at diagnosis of PABC and IDC under 40 years was 32.6 and 34.6 years, respectively (p=0.044). All PABCs were ductal type. Hormone receptors, treatment modalities, and tumor and node stage were not statistically different between PABC and IDC under 40 years. Five-year diseasefree, locoregional relapse-free, distant relapse-free, and overall survival of PABC was 57.1%, 71.3%, 56.4%, and 70.0%, respectively. Survival was not significantly different between two groups. In Cox°Øs models, PABC was not associated with survival outcomes. Among PABCs, there was no statistical difference in survival between patients diagnosed before and after delivery. Conclusion : Pregnancy itself does not increase the risk of poorer outcomes among young breast cancer patients. Vigilant diagnosis and multidisciplinary treatment should be recommended to best manage woman with PABC and her baby.
Keywords: Breast neoplasms | Pregnancy | Prognosis | Survival
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