Risk factors of locoregional recurrences in breast cancer

Park, Inseok; Park, Kyeongmee; Han, Sehwan; Kim, Ji-Young; Kim, Ki Whan; Bae, Byung Noe; Yang, Keun Ho; Gwak, Geumhee; Cho, Hyunjin; Park, Sungjin

doi:2011.7.1.66

Korean Journal of Clinical Oncology > Article

ORIGINAL ARTICLE

Korean J Clin Oncol. 2011;7(1): 66-71. doi: https://doi.org/10.14216/kjco.11011

Risk factors of locoregional recurrences in breast cancer

Inseok Park¹, Kyeongmee Park², Sehwan Han¹, Ji-Young Kim³, Ki Whan Kim¹, Byung Noe Bae¹, Keun Ho Yang¹, Geumhee Gwak¹, Hyunjin Cho¹, Sungjin Park⁴

¹Department of Surgery, Inje University Sanggye Paik Hospital
²Department of Pathology, Inje University Sanggye Paik Hospital
³Department of Radiology, Inje University Sanggye Paik Hospital
⁴Department of Surgery, Inje University Haeundae Paik Hospital

유방암 환자에서 국소구역 재발과 관련된 인자

박인석¹, 박경미², 한세환¹, 김지영³, 김기환¹, 배병노¹, 양근호¹, 곽금희¹, 조현진¹, 박성진⁴

^¹인제대학교 상계백병원 외과학교실
^²인제대학교 상계백병원 병리학교실
^³인제대학교 상계백병원 영상의학교실
^⁴인제대학교 해운대 백병원 외과학교실

Corresponding Author: Geumhee Gwak ,Tel: +82-2-950-1022, Fax: +82-2-933-9389, Email: gsrad@hanmail.net

Received: May 23, 2011; Accepted: June 20, 2011.

ABSTRACT

Purpose: Significant proportion of breast cancer patients with locoregional recurrence eventually die of their disease. This study was performed to investigate the risk factors associated with locoregional recurrence of breast cancer after breast conserving surgery.
Methods: We reviewed the medical records of 302 patients with breast cancer who underwent breast conserving surgery and analyzed the association between locoregional recurrences and clinico-pathological factors of each patients.
Results: The 26 of 302 patients (8.6%) developed locoregional recurrence during a median follow-up of 35.5 months. 18 patients (5.9%) had local recurrence, 6 patients (2.0%) had regional recurrence and 2 patients (0.7%) had locoregional recurrence. On univariate analysis, positive margin (p<0.0001), HER2/neu positive, extensive intraductal component, multiplicity were statistically significant risk factors for locoregional recurrence of breast cancer. On multivariate analysis, positive margin status, HER2/neu positivity and multiplicity were significantly associated with locoregional recurrence after breast conserving surgery.
Conclusion: Our study showed that adequate resection margin is the most important to reduce locoregional recurrence of breast cancer after breast conserving surgery. In addition, HER2/neu amplification or multiplicity increased the locoregional recurrence rate in breast cancer.

Keywords: Breast cancer | locoregional recurrence | margin status | risk factor