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Korean Journal of Clinical Oncology > Article
Korean J Clin Oncol. 2012;8(2): 30-36.         doi: https://doi.org/10.14216/kjco.12014
Results of pre-operative chemotherapy for breast cancer in single institute and Ultrasound mesurements in pathologic response
Moon Il Lee1, Young Up Cho1, Se Joong Kim1, Yoon Jung Kim2
1Departments of Surgery, Inha University School of Medicine, Incheon
2Departments of Radiology, Inha University School of Medicine, Incheon
Corresponding Author: Young Up Cho ,Tel: 032-890-2738, Fax: 032-890-8560, Email: yucho@inha.ac.kr
Received: September 24, 2012;  Accepted: December 20, 2012.
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Purpose: The objective of this study was to evaluate pre-operative chemotherapy of efficacy for breast cancer and re-assessment of breast U/S as modality to test response rate. It was to review correlations the findings of ultrasonography (US) and magnetic resonance (MR) imaging in patients.
Methods: retrospective review identified Ninety-three patients who underwent pre-operative chemotherapy between July, 1996 and December, 2004 were included for this study. We analysed the response rate to adjuvant chemotherapy by reviewing the post operative pathologic report. All patients was performed US after preoperative chemotherapy, and 26 (27.9%) patients was perfomed both US and MRI to compare pre- operation tumor size by U/S and MRI with the post operative pathologic report’s tumor sizes. Statistical analyses were performed with 2-tests and using SPSS 13.0.
Results: The mean age at diagnosis was 46.98(22-74)yrs old. Pre-operation clinical stage was 4 patients for stage I, 40 patients for stage II, 47 patients for stage III and 2 patinets for stage IV. And the tumoral response to preoperative chemotherapy as, 7 patients showed a complete response (CR), 52 patients showed a partial response (PR),24 patients showed a stable disease(SD), and 10 patients showed a progressive disease(PD). Each 5 years overall survival rate were 85.8%, 92.3% ,95.8%, 90.0%.The correlation coefficient (r) of US to pathological tumor size was 0.910 in all tumors, The correlation coefficient (r) of MRI to pathological tumor size was 0.860 in all tumors . (P<0.05)
Conclusions: This study results were similar to other published current studies for neoadjuvant chemotherapy for breast cancer. The correlation between tumor size in U/S and pathological tumor size corresponded best. So it doesn’t need to perfomed MRI for all patients to evaluate response rate. Breast U/S considered as optional modality to evaluate response.
Keywords: Breast cancer | Pre-operative chemotherapy | Response rate | Breast U/S | MRI
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