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Korean Journal of Clinical Oncology > Article
Korean J Clin Oncol. 2012;8(2): 4-9.         doi: https://doi.org/10.14216/kjco.12010
Risk Factors for Recurrence in Colorectal Cancer with N2 Nodal Stage
Joo-Won Jeong, Chul-Min Lee, Seung-Hyun Lee, Byung-Kwon Ahn, Sung-Uhn Baek
Department of Surgery, Kosin University College of Medicine, Busan, Korea
Corresponding Author: Seung-Hyun Lee ,Tel: +82.51-990-6462, Fax: +82.51-246-6093, Email: gscrslsh@hanmail.net
Received: October 2, 2012;  Accepted: December 25, 2012.
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Purpose: The aim of this study is to figure out the clinicopathologic factors associated with recurrence in colorectal cancers with four or more lymph node metastasis (N2 stage). Material and Method: From 2004, Jan to 2006, Dec, a total of 675 patients with colorectal adenocarcinoma were underwent surgery in our hospital. One hundred thirty patients with N2 stage were selected for retrospective review with medical records. Clinicopatholotic factors, such as sex, age, preoperative CEA, tumor location, tumor size, tumor differentiation, T-stage, were studied.
Results: Of the 130 patients, eighty-seven patients were underwent radical surgery for colorectal adenocarcinoma. Mean age was 60.6 (34-86 years). Tumors were located in the colon, 25 patients and the rectum 62 patients. Mean tumor size was 5.8 (2.0-19 cm). With TNM classification, T2, T3, T4 were 1, 80, 6 patients, respectively. Mean number of retrieved lymph node was 21.1 (7-110). Mean follow-up period was 30.5 (5-48 months). Recurrence was identified in 34 patients (39.1%). According to tumor differentiation, recurrence rate was 36.8% of well and moderate differentiation, 54.5% of poor differentiation (p=0.327). Recurrence rate was 37.5% in T3 stage, and 66.7% in T4 stage (p=0.267).
Conclusions: Recurrence rate was not different significantly according to clinicopathologic factors in colorectal adenocarcinoma with N2 stage after radical surgery. Further study is necessary to identify the risk factor for recurrence in colorectal adenocarcinoma with N2 stage.
Keywords: Colorecal cancer | Stage | Lymph Node | Risk Factor
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