| The Relationship between the progression of
colorectal cancer and microRNA polymorphisms |
| Ho Jin Chang1, Nam Keun Kim2, Young Joo Jeon2, Jong Woo Kim1 |
1Department of Surgery, School of Medicine, CHA University, Seongnam, South Korea
2Institute for Clinical Research, School of Medicine, CHA University, Seongnam, South Korea |
| 대장암의 진행과 microRNA 유전자 다양성과의 관계 |
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장호진1, 김남근2, 전영주2, 김종우1 |
1차 의과학 대학교, 외과학 교실
2차 의과학 대학교, 임상연구소 |
| Corresponding Author:
Jong Woo Kim ,Tel: +82-31-780-5250, Fax: +82-31-780-5259, Email: kjw@cha.ac.kr |
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Received: September 23, 2011; Accepted: October 20, 2011. |
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| ABSTRACT |
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Purpose : MicroRNA(miRNA) is related not only with basic biologic process but with regulatory functions of
diverse diseases including cancer. Although it is non-coding RNA of small nucleotides(18~23), nucleotide variation
within primary(pri)- or precursor(pre)-miRNA might affect the mature process of miRNA and can cange it. And
then we aim to elucidate the relationship between 4 kinds of pre-miRNA and clinical progress of colorectal cancer
such as tumor stage, depth of invasion and regional lymph nodes metastasis.
Methods : DNA was extracted from blood samples of 160 patients who underwent operation on colorectal cancers
during recent 2 years and has-mir-146aC>G, has-mir-149T>C, has-mir-196a2T>C and has-mir-499A>G
polymorphisams were genotyped by PCR-RFLP.
Results : There was no relationship between the polymorphism distributions of 4 kinds of pre-miRNA and any
clinical progresses of colorectal cancer.
Conclusion : Although we were unable to find out significant relation between two categories, further active
studies with miRNAs and cancers shoud be carried on. |
| Keywords:
MicroRNA | polymorphism | Colorectal cancer |
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